P2RX7 Purinoceptor as a Therapeutic Target—The Second Coming?

P2RX7 Purinoceptor: A Therapeutic Target for Ameliorating the Symptoms of Duchenne Muscular Dystrophy

BACKGROUND Duchenne muscular dystrophy (DMD) is the most common inherited muscle disease, leading to severe disability and death in young men. Death is caused by the progressive degeneration of striated muscles aggravated by sterile inflammation. The pleiotropic effects of the mutant gene also include cognitive and behavioral impairments and low bone density. Current interventions in DMD are pa...

Purinoceptor regulation of renal tubular transport is coming of age.

THE KIDNEY PLAYS a central role in regulating blood pressure, body fluid volume, body fluid composition, and electrolyte and water balance. Generations of effort have gone into understanding the tubular and vascular interactions that confer incredible fidelity in accomplishing these essential functions. While P2 purinergic signaling systems were investigated in other organ systems for some time...

Symbolic Significance of Yeats's "The Second Coming"

The Second Coming

The definitions and characteristics of the out-of-body experience were examined. It was concluded that none of the various definitions are specific enough wRh regard to the idea of an actual physical split between the consciousness and the body. The experimental evidence was outlined, the weaknesses highlighted and alternative explanations were given. The out-of-body experience associated with ...

FGF21 and the Second Coming of PPARγ

Peptide hormone fibroblast growth factor-21 (FGF21) has insulin-mimetic properties. Dutchak et al. now suggest that FGF21 also acts in an autocrine fashion in adipocytes and is required to mediate effects of the PPARγ agonist class of antidiabetic drugs. Does this new property improve FGF21's fledgling clinical prospects or endorse a clinical resuscitation of PPARγ agonists?